Реферат
Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al. describe the role of soluble interleukin-6 receptor (sIL-6R) in IL-6 trans-signaling and how understanding the IL-6:sIL-6R axis might help define and treat COVID-19 cytokine storm syndrome.
Тема - темы
COVID-19/pathology , Cytokine Release Syndrome/diagnosis , Receptors, Interleukin-6/analysis , Antibodies, Monoclonal/immunology , Antibodies, Monoclonal/pharmacology , COVID-19/complications , COVID-19/virology , Cytokine Release Syndrome/etiology , Humans , Interleukin-6/analysis , Interleukin-6/immunology , SARS-CoV-2/isolation & purification , Signal Transduction/drug effectsРеферат
Cytokines are a family of proteins which play a major role in the regulation of the immune system and the development of several diseases, from rheumatoid arthritis to cancer and, more recently, COVID-19. Therefore, many efforts are currently being developed to improve therapy and diagnosis, as well as to produce inhibitory drugs and biosensors for a rapid, minimally invasive, and effective detection. In this regard, even more efficient cytokine receptors are under investigation. In this paper we analyze a set of IL-6 cytokine receptors, investigating their topological features by means of a theoretical approach. Our results suggest a topological indicator that may help in the identification of those receptors having the highest complementarity with the protein, a feature expected to ensure a stable binding. Furthermore, we propose and discuss the use of these receptors in an idealized experimental setup.